Table 1.

Receptors on microglia that are involved in α-Synuclein-induced responses.

Receptor	α-Synuclein phase	Pro/anti-inflammation	Description	Reference
CD14 and TLR4	Monomer	Pro-inflammation	Mediating phagocytosis of α-Synuclein	Kitchens (2000), Muroi et al. (2002), Stefanova et al. (2011) and Fellner et al. (2013)
TLR1 and TLR2	Oligomer	Pro-inflammation	Relating to α-Synuclein toxicity and inflammation	Klegeris et al. (2008), Wilms et al. (2009), Prabhakaran et al. (2011), Kim et al. (2013) and Daniele et al. (2015)
CD36	Monomer	Pro-inflammation	Mediating oxidative stress	Ferreira and Romero-Ramos (2018)
P2X7R and eATP	Oligomer	Pro-inflammation	Mediating oxidative stress	Jiang et al. (2015)
CD11b/CD18	Oligomer/fibril	Pro-inflammation	Mediating oxidative stress	Wang et al. (2015)
EP2	Oligomer	Pro-inflammation	Regulating α-Synuclein aggregation and associated neurotoxicity	Jin et al. (2007)
Ion transport channel	Nitrated α-Synuclein	Pro-inflammation	Mediating oxidative stress	Thomas et al. (2007)
FcγR	Fibril and IgG	Anti-inflammation	Preventing hyper-activation and inducing SHP-1 activation	Smith and Clatworthy (2010), Choi et al. (2015) and Chauhan et al. (2017)
MHC II	Peptides	Anti-inflammation	Inducing α-Synuclein degradation	Sulzer et al. (2017)