Table 1.
Summary of immunohistochemical scoring of BON tumor sections with median intensity and extent scores for each treatment group. Immunohistochemical sections were scored according to staining intensity (negative −, weak +, moderate ++, or strong +++). For reference images, see figure S1. Extent score was defined on a scale of 0–3 (0 ≤ 25%, 25% < 1 ≤ 50%, 50% < 2 ≤ 75%, 3 > 75%)
| Target | SSTR2 | EGFR | VEGFR | HSP70 | ||||
|---|---|---|---|---|---|---|---|---|
| Intensity | Extent | Intensity | Extent | Intensity | Extent | Intensity | Extent | |
| Control | +++ | 1 | ++ | 3 | +++ | 3 | ++ | 3 |
| Onalespib | ++ | 1 | +/++ | 3 | +/++ | 3 | ++ | 3 |
| 177Lu-DOTATATE | ++ | 1 | +++ | 3 | ++/+++ | 3 | + | 2 |
| Combination | +++ | 1 | +/++ | 2 | + | 3 | ++ | 3 |