Table 1.
The baseline characteristics of 441 ICB-treated patients.
| Characteristics | PBRM1 wild type (N = 415) | PBRM1 mutant (N = 26) | P value |
|---|---|---|---|
| Sex (%) | 0.207 | ||
| Male | 194 (46.7) | 16 (61.5) | |
| Female | 221 (53.3) | 10 (38.5) | |
| Age (%) | 0.199 | ||
| <31 | 1 (0.3) | 0 (0) | |
| 31–50 | 36 (9.9) | 1 (4.3) | |
| 50–60 | 80 (22.1) | 2 (8.7) | |
| 61–70 | 124 (34.3) | 7 (30.4) | |
| >71 | 121 (33.4) | 13 (56.5) | |
| NA | 53 | 3 | |
| Smoke (%) | 0.133 | ||
| Never | 60 (21.4) | 0 (0) | |
| Ever | 208 (74.0) | 14 (93.3) | |
| Current | 13 (4.6) | 1 (6.7) | |
| NA | 134 | 11 | |
| Pathology (%) | 0.697 | ||
| LUAD | 323 (77.8) | 21 (80.8) | |
| LUSC | 54 (13.0) | 2 (7.7) | |
| Other | 38 (9.2) | 3 (11.5) | |
| Therapy (%) | 0.210 | ||
| Mono | 377 (90.8) | 26 (100) | |
| Combo | 38 (9.2) | 0 (0) | |
| Lines of treatment (mean (SD)) | 2.24 (1.15) | 2.33 (0.89) | 0.775 |