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. 2020 Mar 16;10:4846. doi: 10.1038/s41598-020-61854-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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CNV tracks for a paired normal/cancer samples deposited in GEO with sample IDs GSM276881 and GSM276880. GSM276880 is a glioblastoma sample. GSM276881 is its peripheral blood control. The CNV tracks are consisted of two panels. Upper panel indicates the total copy number, represented by logR ratio ( $l o g_{2} \frac{c o p y n u m b e r}{r e f e r e n c e c o p y n u m b e r}$ at any probe) Namely, logR = 0 indicates a position with normal two copies, logR > 0 indicates a copy number gain and logR < 0 indicates a copy number loss. Lower panel indicates the allele specific copy number, represented by B-allele frequency (BAF, $\frac{N o . B a l l e l e c o p y}{T o t a l c o p y n u m b e r}$ ). Any given SNP position can have a value between 0 and 1. A line at 0.5 indicates a heterozygous region. Compared to the unaltered genome (A), the cancerous counterpart (lower) has copy number loss in chr8, 10p, 18, 19qter, 22q and copy-neutral loss of heterozygocity in chr9,12q, accounting for 18.2% of genome.