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. 2020 Mar 16;11:1413. doi: 10.1038/s41467-020-15147-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Source data are provided as a Source Data file. a Somatic membrane potential (top) and its time derivative (bottom) in response to the activation of 30 synapses in control condition (grey) and with a Na⁺ hotspot in the middle of the stimulated branch (green). b Example responses in control conditions (grey) and with strong dendritic branches (coloured) without (top) and with LTP (bottom) in the case of 10 synapse per cluster when the replayed trajectory maximally overlapped with the place fields of the clustered synapses (trajectory start = 80 cm). Action potentials were truncated. c Average somatic Vm depolarisation amplitude during the SPW in control conditions (filled circles) and with strong dendritic branches (empty symbols) as a function of cluster size without (top) and with LTP (bottom) with trajectory start = 80 cm. The presence of strong branches increases the depolarisation and the spike count when the synaptic clusters are large. Symbols show mean and SD of 16 simulations with different inputs but identical cluster arrangements. d Similar to c, but the average spike count during the SPW is shown.