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. 2019 Nov 27;45(5):745–752. doi: 10.1038/s41386-019-0580-8

Fig. 2. [H-3]-(+)-PHNO binding and D3 mRNA levels in mice.

Fig. 2

a Comparison of mouse [H-3]-(+)-PHNO binding between CC genotypes (n = 10, white circles), AC (n = 10, gray circles), and AA (n = 10, black circles) rs324420 FAAH genotypes (AA and AC genotype groups are combined together). b Comparison of D3 mRNA levels in CC (n = 10, white circles), AC (n = 10, gray circles), and AA (n = 10, black circles) rs324420 FAAH genotypes. In situ hybridization was performed with a S-35-labeled probe (AA and AC genotype groups are combined together). c D3 mRNA autoradiographic images from in situ hybridization with D3-specific S-35 riboprobe from mice with CC, AC, and AA rs324420 FAAH genotypes, respectively. Asterisk indicates significant differences in [H-3]-(+)-PHNO binding or D3 mRNA levels between the two rs324420 FAAH genotype groups (CC vs. AA + AC). There were no significant differences between AA and AC groups. NAcc-C nucleus accumbens Core, NAcc-Sh nucleus accumbens shell, VP/I Call ventral pallidum (anterior)/Islands of Calleja, VP/MPOA ventral palidum (medial)/medial preoptic area, ICj-M Islands of Calleja (major), Olf Tub olfactory tubercle, CPu-DM Caudate-putamen (dorsomedial), CPu-DL Caudate-putamen (dorsolateral), CPu-VL Caudate-putamen (ventrolateral), CPu-Lat band Caudate-putamen (exterior lateral band), SNC Substantia nigra compacta, VTA ventral tegmental area, CPu-A Caudate-putamen (anterior pole), Lat Str stripe lateral striatal stripe.