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. 2020 Mar 16;10:4744. doi: 10.1038/s41598-020-61734-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Expression of key regulated miRNAs during hESC-chondrogenesis. Expression during directed chondrogenesis of hESCs, of known (A) stem cell-associated microRNAs, (B) microRNAs that regulate cartilage development, (C,D) Hox complex microRNAs, (E) microRNAs reported to be upregulated in prechondrocytes, (F) microRNAs reported to be upregulated in hypertrophic chondrocytes. (G) Summary of transcript and microRNA expression changes during hESC chondrogenesis.