Table 2.

Regional MA1-derived [¹¹C]CIMBI-36 distribution volumes (V_T) and binding potentials (BP_ND), before and 3 h after d-amphetamine challenge.

	VT		BPND		Delta-BPND (%)
	Baseline (Av ± SD)	Post-d-amph (Av ± SD)	Baseline (Av ± SD)	Post-d-amph (Av ± SD)	Av ± SD	p-value
MA1
Frontal Ctx	26.93 ± 5.43	22.85 ± 3.20	1.04 ± 0.31	0.87 ± 0.20	14.06 ± 12.94	0.002
Parietal Ctx	25.86 ± 5.14	22.26 ± 3.08	0.96 ± 0.28	0.82 ± 0.19	11.03 ± 18.72	0.011
Temporal Ctx	27.41 ± 4.81	23.68 ± 3.50	1.07 ± 0.25	0.93 ± 0.17	11.22 ± 14.78	0.009
Occipital Ctx	26.88 ± 4.74	23.48 ± 3.53	1.03 ± 0.24	0.91 ± 0.18	9.48 ± 15.56	0.013
Cerebellum	13.21 ± 1.60	12.28 ± 1.42	–	–	–	–
2TCM
Frontal Ctx	27.28 ± 5.57	23.22 ± 3.39	1.06 ± 0.32	0.89 ± 0.20	13.52 ± 13.13	0.002
Parietal Ctx	26.18 ± 5.22	22.60 ± 3.21	0.97 ± 0.29	0.84 ± 0.19	10.29 ± 20.32	0.014
Temporal Ctx	27.83 ± 4.97	24.09 ± 3.72	1.10 ± 0.26	0.95 ± 0.18	10.99 ± 15.22	0.010
Occipital Ctx	27.14 ± 4.78	23.81 ± 3.66	1.05 ± 0.24	0.93 ± 0.18	8.82 ± 16.09	0.018
Cerebellum	13.25 ± 1.63	12.33 ± 1.44	–	–	–	–
SRTM
Frontal Ctx	–	–	0.91 ± 0.33	0.74 ± 0.22	13.71 ± 24.51	0.016
Parietal Ctx	–	–	0.86 ± 0.34	0.72 ± 0.19	7.63 ± 35.89	0.059
Temporal Ctx	–	–	0.93 ± 0.30	0.80 ± 0.19	8.50 ± 25.73	0.063
Occipital Ctx	–	–	0.89 ± 0.27	0.80 ± 0.19	6.98 ± 18.95	0.041
Cerebellum	–	–	–	–	–	–

Delta-BP_ND, or 5-HT release capacity, was calculated as 1 – (BP_ND post-dose/BP_ND baseline)