Fig. 3. VT of [11C]PBR28, adjusted for the effect of TSPO binding genotype, is lower in first episode psychosis patients (FEP, red bars, n = 13) than in healthy controls (HC, blue bars, n = 15) without significant differences between regions (df = 1, F = 5.635, p = 0.026; Cohen’s d = 0.936).
The width of the figures represent the probability density at different values of adjusted VT in 17 VOIs and their composite VOI. The VOIs are arranged in order of decreasing maximum mean of HC VT. Thick lines inside the figures indicate the median value, while the thin lines represent upper and lower quartiles. Abbreviations: ACC, anterior cingulate cortex; AMY, amygdala; CAU, caudate nucleus; CER, cerebellum; FC, frontal cortex; HIPP, hippocampus; INS, insula; OCC, occipital cortex; OFC, orbitofrontal cortex; PAR, parietal cortex; PCC, posterior cingulate cortex; PFC, prefrontal cortex; PHIPP, parahippocampal gyrus; PUT, putamen; TEMP, temporal cortex; THA, thalamus; TOTAL, composite VOI.