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. 2020 Mar 16;10:94. doi: 10.1038/s41398-020-0776-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a–e Representative planes of mean [¹¹C]PBR28 V_T in parametric images overlaid upon a anatomical reference template: a FEP HAB genotype subjects (n=8), b FEP MAB genotype subjects (n=5), c FEP LAB genotype subject (n=1), d HC HAB genotype subjects (n=9) and e HC MAB genotype subjects (n=6) separately. The color representation of V_T, shown in the color bar on the lower left, is adjusted to to cover the variance between LAB, MAB, and HAB subjects in both groups. f A statistical parametric mapping (SPM) analysis shows one extensive cluster of lower V_T in FEPs (n=13) compared to HCs (n=15) visualized here with a red to yellow gradient representing voxel-wise T-score values. The lower limit of the color bar on the lower right shows the T-score height threshold and the upper limit denotes maximum peak value.