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. 2020 Mar 16;10:4823. doi: 10.1038/s41598-020-61844-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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IFC in the cingulo-opercular network (a) and right fronto-parietal network (b) in older healthy participants. The clusters significantly related to phasic alerting effects (red) are overlaid on intra-network iFC (blue). The spatial maps are obtained by a combined independent component analysis dual regression approach. Behaviour-iFC associations were tested using a voxel-wise multiple regression, controlling for age, sex, head motion, and education (p < 0.05 FWE corrected at cluster level). The results are presented on a standard anatomical MNI152 template using MRIcroGL (https://www.mccauslandcenter.sc.edu/mricrogl/source); slice numbers in transverse plane are indicated.