Table 2.
Various GRSs comprised of 941 BMI-associated genetic variants of the three groups of mother-child pairs.
| Genetic risk scores (GRSs) comprised of 941 BMI-associated genetic variants | REF | MO-OW | P for difference between the MO-OW and the REF groups | CH-OW | P for difference between the CH-OW and the REF groups | |||
|---|---|---|---|---|---|---|---|---|
| N | Mean (SD) | N | Mean (SD) | N | Mean (SD) | |||
| Child GRS | ||||||||
| Number of BMI-increasing risk alleles | 499 | 901.9 (18.2) | 413 | 908.0 (18.1) | <0.001 | 762 | 908.0 (18.3) | <0.001 |
| Maternal GRS | ||||||||
| Number of BMI-increasing risk alleles | 499 | 902.7 (17.4) | 413 | 910.6 (18.1) | <0.001 | 762 | 905.3 (18.0) | 0.01 |
| Maternal transmitted GRS | ||||||||
| Number of BMI-increasing risk alleles | 499 | 444.5 (12.2) | 413 | 448.5 (12.1) | <0.001 | 762 | 447.8 (12.4) | <0.001 |
| Paternal transmitted GRS | ||||||||
| Number of BMI-increasing risk alleles | 499 | 446.3 (12.8) | 413 | 448.0 (12.8) | 0.04 | 762 | 449.5 (12.2) | <0.001 |
| Maternal non-transmitted GRS | ||||||||
| Number of BMI-increasing risk alleles | 499 | 446.8 (12.5) | 413 | 451.0 (12.5) | <0.001 | 762 | 446.6 (12.5) | 0.79 |
The genetic risk scores (GRSs) were comprised of 941 BMI-associated genetic variants, meaning that each mother and child carried 1882 alleles that were either BMI-increasing or decreasing. The GRSs are expressed as the number of the BMI-increasing alleles.
We tested for differences in GRSs comprised of 941 BMI-associated genetic variants between the mother-child groups at the extremities of the BMI distribution (MO-OW and CH-OW groups) and the REF group using t-tests.
CH-OW: Children with overweight and their mothers (children with overweight group); GRS: Genetic risk score; OW-MO: Mothers with overweight and their children (mothers with overweight group); REF: Randomly selected mothers and their children (reference group).