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. 2020 Mar 16;10:4827. doi: 10.1038/s41598-020-59059-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of 5 on apoptosis and caspase activation of A375 and 518A2 cells. Cells were exposed to 5 for 48 h, and apoptosis (A) and caspase activation (B) were assessed by flow cytometry. The data are presented as a representative dot plot or histogram (left panel) and mean ± SD obtained from three independent experiments (right panel). *p < 0.05 refers to untreated cultures.