Table 1.
IC50 values for compounds 4a–c, 5, and 6 for the growth inhibition of different melanoma and colon cancer cell lines, obtained from MTT and CV assays (three independent experiments each).
| IC50 (µM) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Compound | 4a | 4b | 4c | 5 | 6 | ||||||
| Test | MTT | CV | MTT | CV | MTT | CV | MTT | CV | MTT | CV | |
| Cell line* | A375 | 20.15 ± 1.26 | 15.95 ± 1.65 | 16.85 ± 1.35 | 14.05 ± 0.75 | 17.95 ± 1.26 | 10.5 ± 0.75 | 4.25 ± 1.65 | 4.7 ± 0.30 | >50 | >50 |
| 518A2 | 18.95 ± 1.63 | 21.4 ± 0.42 | 13.75 ± 0.21 | 14.75 ± 0.92 | 36.35 ± 0.21 | 41.2 ± 2.12 | 5.15 ± 0.64 | 5.5 ± 0.57 | 36.85 ± 0.49 | 49.7 ± 0.42 | |
| B16 | 30.8 ± 2.81 | 30.55 ± 3.86 | 18 ± 1.71 | 22.15 ± 0.65 | 26.05 ± 2.49 | 30.8 ± 3.22 | 10.1 ± 0.40 | 11.45 ± 1.05 | >50 | >50 | |
| B16F10 | 24.3 ± 2.01 | 25.4 ± 2.41 | 27.3 ± 2.82 | 26.6 ± 2.62 | 28 ± 2.62 | 26.5 ± 2.62 | 7.95 ± 3.06 | 7.65 ± 0.26 | >50 | >50 | |
| HCT116 | 13.5 ± 0 | 12.8 ± 0.5 | 42.5 ± 1.42 | 35.9 ± 0 | 22.15 ± 0.95 | 19.25 ± 1.46 | 8.9 ± 0 | 9.95 ± 0.95 | >50 | >50 | |
| CT26CL25 | 42.65 ± 3.17 | 37.2 ± 2.21 | 38.1 ± 0.9 | 36.05 ± 1.25 | 28.45 ± 2.46 | 29.25 ± 2.86 | 31.45 ± 3.27 | 29.4 ± 2.12 | >50 | >50 | |
| SW480 | 22.8 ± 0.7 | 19 ± 1.91 | 42.5 ± 0 | 35.9 ± 0 | 24.15 ± 1.05 | 26.8 ± 2.81 | 16.6 ± 1.01 | 8.6 ± 0.21 | >50 | >50 | |
| SW620 | 24.7 ± 0.42 | 24.75 ± 0.35 | 19.25 ± 0.78 | 21.75 ± 0.64 | 35.7 ± 0.85 | 44.35 ± 1.77 | 10.5 ± 0.14 | 10.75 ± 0.21 | >50 | >50 | |
*A375, human melanoma; 518A2, human melanoma; HCT116, human colon carcinoma; SW480, human colon carcinoma; SW620, human colon carcinoma; B16, mouse solid melanoma; B16F10, mouse metastatic melanoma; CT25CL26, mouse colon carcinoma.