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. 2020 Mar 16;10:4804. doi: 10.1038/s41598-020-61677-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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cAMP-mediated activation of PKA reduces the unitary conductance of wild-type α3GlyRs. (A) Single channel current traces obtained from cells co-expressing α3GlyRs and bPAC in the absence and presence of blue light. Calibration bar, 5 pA, 1 s. (B) Time course of the average amplitude of the events after blue light exposure (from minute 3) or in control conditions (12 minutes in no light condition). (C) The histograms show the amplitude distributions of control cells (left) and cells stimulated with blue light (right). (D) The plot summarizes the main conductance of α3GlyRs after blue light exposure or after the application of 8-Br-cAMP. Differences were significant (***P < 0.001; ANOVA followed by Bonferroni post-hoc test, F(2, 14) = 123.4). Control, n = 5; Blue light, n = 5; 8-Br-cAMP, n = 5.