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. 2020 Mar 16;10:4751. doi: 10.1038/s41598-020-61825-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PTH-induced changes in the number and motility of OBs and OCs (a) Representative intravital two-photon microscopy images of ectopic bone formation in untreated (upper panels) and PTH-treated (lower panels) Col2.3-ECFP/TRAP-tdTomato mice from day 7 to day 21 after CS implantation. Cyan: OBs expressing Col2.3-ECFP; red: OCs expressing TRAP-tdTomato. Scale bar, 50 μm. (b) Changes in the number of OBs/visual field. n = 4–5/group. (c) Mean velocity of OBs/visual field. Data points (without/with PTH treatment, n = 141/253, 167/168, and 129/160 on days 10, 14, and 21, respectively) represent single cells collected from three mice/group. (d) Changes in the number of OCs/visual field. n = 4–5/group. (e) Changes in CDI of OCs/visual field, with and without PTH treatment. Data points (without/with PTH treatment, n = 100/84 and 72/84 on days 14 and 21, respectively) represent single cells collected from three mice/group. Data are presented as means ± SD. *P < 0.05; **P < 0.01; NS, not significant (Mann-Whitney test).