Figure 5.

Clinical validation of S100A6 expression correlation to acid phenotype in breast cancer. (A) TMA analysis of 160 biopsy cores stained with S100A6 antibody showed increased expression of this protein from normal to DCIS, IDC, and IDC with Mets. Data are shown as mean with standard deviation as error bar. (B) Kaplan-Meier graph comparing DCIS patient's survival with low expression of S100A6 (Below the average) to patients with high S100A6 expression. Patients with high expression survived less than patients with low expression. (C) Representative images of core biopsies stained for both LAMP2b and S100A6 on sequential cuts. (D) Correlation analysis of LAMP2b and S100A6 in different stages of breast cancer.