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. 2020 Mar 10;14:43. doi: 10.3389/fncel.2020.00043

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Copyright © 2020 Almuslehi, Sen, Shortland, Mahns and Coorssen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of cuprizone (CPZ)-feeding or castration (Cx) on thymus and spleen size and weight. Representative examples of the gross appearance of the thymus and spleen organs (A) and quantification of the wet weights (B) of the different treatment groups used in the three different studies. In gondally intact (Gi) males and females, CPZ-feeding produced a dose-dependent reduction in immune organ mass (p < 0.05). In the Cx groups, Cx significantly increased thymic mass compared to Gi males and females (p < 0.05) and prevented CPZ-induced thymic and splenic atrophy (p > 0.05). In Gi female mice CPZ-induced atrophy was indistinguishable to that observed in Gi males. Data are presented as mean ± SEM, one-way analysis of variance (ANOVA), n = 10 thymic or spleens/group. *Indicates a significant difference from Ctrl (p < 0.05).