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. 2020 Mar 10;11:372. doi: 10.3389/fimmu.2020.00372

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Copyright © 2020 Pirozyan, McGuire, Emran, Tseng, Tiffen, Lee, Carlino, Menzies, Long, Scolyer, Fazekas de St Groth and Hersey.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression levels of inhibitory receptors on CD4 and CD8 T cells by treatment outcome. PBMCs were analyzed for expression of CD39, PD-1, TIGIT, TIM-3, and KLRG1 on CD4 and CD8 T cells. There were no significant differences in expression between the groups at any timepoint. Expression of (A) PD-1 and (B) CD39 showed changes within individual subjects over the course of therapy, while TIM-3, TIGIT, and KLRG1 did not (not shown). Baseline, open circles; week 6, blue filled circles; 1 year, red filled circles. Differences in frequencies of immune cell populations between the 3 timepoints were assessed using a repeated measures mixed effects analysis followed by Tukey's multiple comparisons test and p-values are indicated.