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. 2020 Mar 10;11:271. doi: 10.3389/fpls.2020.00271

FIGURE 1.

FIGURE 1

Integration of Ethylene into Auxin Signaling in Arabidopsis Root Development. Environmental cues trigger the biosynthesis of ethylene in Arabidopsis, and then ethylene binds to ETR receptors to inactivate CTR1, which functions to repress EIN2. When EIN2 is released by CTR1, it can be cleaved and then helps to stabilize EIN3/EIL1, leading to the activation of downstream transcriptional cascades. Ethylene inhibits primary root growth by regulating auxin biosynthesis, transport, and signaling. ERF1 and HB52 function as crosstalk nodes between ethylene and auxin in this process. An increase in endogenous ethylene enhances auxin transport and reduces lateral root formation depending on AUX1, PIN3, and PIN7. The ERF1 and HB52 regulatory modules are part of the molecular mechanisms in the adaptive response of root growth to environmental cues.