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. 2020 Mar 10;11:252. doi: 10.3389/fphar.2020.00252

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Copyright © 2020 Chan, Cheung, Zhang, Fu, Tan, Norimoto, Wang and Feng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pre-treatment but not co-treatment or post-treatment of HLJDD improved CPT-11-induced diarrhea. (A) Showed the treatment scheme; (B) showed that pre-treatment but not co-treatment or post-treatment of HLJDD improved body weight loss induced by CPT-11; (C) showed that pre-treatment but not co-treatment or post-treatment of HLJDD improved diarrhea score induced by CPT-11; (D) showed that pre-treatment but not co-treatment or post-treatment of HLJDD improved the histological structure of jejunum damaged by CPT-11. ***p < 0.001 when compared with the model group.