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. 2020 Mar 10;11:252. doi: 10.3389/fphar.2020.00252

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Copyright © 2020 Chan, Cheung, Zhang, Fu, Tan, Norimoto, Wang and Feng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pre-treatment of HLJDD reduced intestinal cell apoptosis and improved renewal in chemotherapy-treated mice. (A) Showed that pre-treatment of HLJDD could significantly reduce the positive TUNEL signal in the intestinal section of chemotherapy-treated mice; (B) showed that pre-treatment of HLJDD could significantly reduce the expression of cleaved caspases-3 in the intestinal section of chemotherapy-treated mice; (C) showed that pre-treatment of HLJDD could significantly improve the renewal-associated Ki67 expression in the intestinal section of chemotherapy-treated mice. *p < 0.05, **p < 0.01, ***p < 0.001 when compared with the model group.