Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Mar 10;11:252. doi: 10.3389/fphar.2020.00252

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Chan, Cheung, Zhang, Fu, Tan, Norimoto, Wang and Feng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Pre-treatment induced CD44 expression and activation of its downstream Wnt signaling in the intestinal cell of chemotherapy-treated mice. (A) showed the volcano plots of gene expression in the intestine challenged by 5-Fu (GSE28873) and CPT-11 (GSE11722). Genes with relative expression of log2(fold change) > 1 and log10(p-value) > 2 were shortlisted; (B) showed overlapped of genes with significant expression change after 5-Fu and CPT-11 treatment, and genes with expression affected by compounds in HLJDD. Tow genes, CD44 and CAV1, were the common genes among the three populations; (C) showed that pre-treatment of HLJDD could significantly improve the CD44 expression in the intestinal section of chemotherapy-treated mice; (D) showed that expression of stemness-related gene, including lgr5, ascl2 and oflm4 in the intestine cells in the intestine of chemotherapy-treated mice was induced by pre-treatment of HLJDD; (E) showed that expression of Wnt pathway-related genes, including Wnt3, Axin2, Fzd5 and Pygo2, in the intestine cells in the intestine of chemotherapy-treated mice was induced by pre-treatment of HLJDD; *p < 0.05, **p < 0.01, ***p < 0.001 when compared with the model group.