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. 2020 Mar 10;11:252. doi: 10.3389/fphar.2020.00252

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Copyright © 2020 Chan, Cheung, Zhang, Fu, Tan, Norimoto, Wang and Feng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pre-treatment of HLJDD improved tumor response and diarrhea in clinical chemotherapy regimens FOLFOX- and FOLFIRI-treated colon cancer in mice. (A) Showed the regimen plan of FOLFOX and FOLFIRI; (B,C) showed that 2-week pretreatment of HLJDD at 200 mg/kg could significantly potentiate the tumor suppressive effect FOLFOX and FOLFIRI on orthotopic colon cancer; (D) showed that 2-week pretreatment of HLJDD at 200 mg/kg could significantly improve the diarrhea induced by FOLFOX and FOLFIRI; (E) showed that 2-week pretreatment of HLJDD at 200 mg/kg could improve the histological structure of jejunum in FOLFOX- and FOLFIRI-treated colon cancer in mice. **p < 0.01, ***p < 0.001 when compared with the respective chemotherapy regimen group.