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. 2020 Mar 10;11:241. doi: 10.3389/fphar.2020.00241

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Copyright © 2020 Chen, Ma, Yang, Li, Lin and Gong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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rhFGF21 significantly reduces tubular cell damage in AKI mouse model. (A) Changes in mouse BUN levels. (B) Changes in mouse serum creatinine levels. (C–F) Representative immunoblotting analysis of TIM-1, C-caspase 3, and Bax in mouse renal tissue. Expression levels of TIM-1, C-caspase 3, and Bax were quantified by densitometry, with GAPDH as protein loading control. (G) H&E staining of mouse renal tissue (scale bar: 100 μm). (H) Histopathological scores of H&E staining of mouse kidney tissue. ***P < 0.001, **P < 0.01, *P < 0.05.