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. 2020 Mar 10;11:414. doi: 10.3389/fimmu.2020.00414

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Copyright © 2020 Gong, Tai, Huang, Xiao, Mo, Wang, Han, Zhou, Chen, Tang, Zhao, Xu, Gong, Zhang, Yang, Wang and Xiao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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STAT3 inhibition and AMPK activation showed similar anti-inflammatory effect in mice. Mice were intraperitoneally injected with LPS (15 mg/kg) alone or LPS with BBR (10 mg/kg) or S3I-201 (5 mg/kg) and were sacrificed 6 h after LPS injection. (A) HE-staining images of lung tissue. Black arrows indicate infiltration of inflammatory cells. (B) Relative mRNA levels of inflammatory genes in lung tissue. (C) Relative mRNA levels of the STAT3 downstream genes Socs3 and Cox2 in lung tissue. Data are presented as means ± SD from 3 independent experiments **p < 0.01, ***p < 0.001, compared to LPS alone group; ^#p < 0.05, ^##p < 0.01, ^###p < 0.001, compared to LPS + BBR group. Bar represents 50 μm.