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Predicted and experimental inhibition constant (Ki) for SHP2 and SHP1 by substrate-derived peptides
The closeness of the predicted and the experimental Ki values suggests the reproducibility of the findings.
| PTP | Predicted Ki | Experimental Ki |
|---|---|---|
| μm | μm | |
| DADEpYL | ||
| SHP1 | 641 | 630.0 |
| SHP2 | 9.72 | 11.97 |
| DAAEpYL | ||
| SHP1 | 650 | No measureable effect |
| SHP2 | 611.38 | 856.8 |
