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. 2020 Jan 31;295(11):3431–3446. doi: 10.1074/jbc.RA119.011191

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© 2020 Wu et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Figure 9. — Melanoma cell line UACC257 does not respond to DNMDP due to lack of AIP expression. A, of 973 CCLE cancer cell lines, only UACC257 cells have an AIP deletion and express no AIP mRNA. B (left), ectopic expression of AIP in UACC257 cells confers DNMDP sensitivity in a 72-h CellTiter-Glo assay. Increased expression of PDE3A similarly confers DNMDP sensitivity. NT, no genes transduced. Right, immunoblots (WB) confirm expression of PDE3A, AIP, and V5-tagged GFP. C, model of DNMDP-induced complex formation between PDE3A and SLFN12. Complex formation is facilitated by AIP.