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. 2020 Jan 16;295(11):3601–3613. doi: 10.1074/jbc.RA119.010489

Figure 2.

Figure 2.

Age-dependent glucose intolerance in Hv1-deficient mice. A and B, basal blood glucose (A) and corresponding serum insulin (B) concentrations after fasting for 6 h in 2- and 6-month-old KO and WT mice (n = 10/genotype). Data are means ± S.D. ***, p < 0.001; KO versus corresponding WT. C–E, HOMA-IR (C), HOMA-β (D) and HOMA-IS (E) parameters calculated from basal blood glucose (A) and corresponding serum insulin (B) concentrations. Data are means ± S.D. *, p < 0.05; ***, p < 0.001; KO versus corresponding WT. F and G, blood glucose levels measured in whole blood following i.p. injection of glucose (2 g/kg of body weight) in 2- and 6-month-old KO and WT mice (F) and AUC (G) (n = 12/genotype). 6-month-old KO mice show more serious glucose intolerance than 2-month-old KO mice. Data are means ± S.E. **, p < 0.01; ***, p < 0.001; KO versus corresponding WT. H, insulin concentrations measured in sera of KO and WT mice following i.p. glucose challenge (2 g/kg of body weight) in 2- and 6-month-old KO and WT mice (n = 8/genotype). Data are means ± S.E. I, blood glucose levels measured in whole blood following i.p. insulin injection (1 unit/kg of body weight) in 2- and 6-month-old KO and WT mice (n = 12/genotype). Data are means ± S.E. *, p < 0.05 versus corresponding WT.