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An overview of the reaction catalyzed by SHMT and its context in the folate cycle. A, the conversion of serine and THF to glycine and MTHF. The green circle highlights the methylene group transferred from l-serine to THF. B, the cellular folate cycle involving SHMT, thymidylate synthase (TS), and dihydrofolate reductase (DHFR). This figure is adapted from Nonaka et al. (46).
