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G9a inhibition potentiates the analgesic effect of the CB1R agonist diminished by nerve injury. A and B, time course of the effect of intrathecal ACEA on the tactile (A) and pressure (B) withdrawal thresholds in SNL rats treated with UNC0638 or DMSO (n = 10 rats/group). Data are shown as means ± S.E. *, p < 0.05; **, p < 0.01; ***, p < 0.001 compared with the respective baseline at time 0 (two-way ANOVA followed by Tukey post hoc test).
