Figure 6.

Ablation of Ehmt2 in DRG neurons augments the analgesic effect of the CB₁R agonist diminished by nerve injury. A–C, time course of the effect of intraperitoneal injection of ACEA (1 and 5 mg/kg) on the tactile (A) and pressure (B) withdrawal thresholds and thermal sensitivity (C) of 8 Ehmt2-cKO and 7 WT control mice subjected to SNI. Data are shown as means ± S.E. *, p < 0.05; **, p < 0.01; ***, p < 0.001 compared with the respective baseline at time 0 (two-way ANOVA followed by Tukey post hoc test).