Table 5.

Harrell’s C-statistics for evaluation of overall adequacy of risk prediction procedures

Protein	Model 3 vs model with add-on of each protein
GDF-15	0.693 vs 0.694
MMP-2	0.693 vs 0.698
UPAR	0.693 vs 0.695
OPN	0.693 vs 0.701
IGFBP-7	0.693 vs 0.696
PON3	0.693 vs 0.693
TNFR1	0.693 vs 0.693
NT-proBNP	0.693 vs 0.750
CHI3L1	0.693 vs 0.693
FABP-4	0.693 vs 0.696
GAL-4	0.693 vs 0.694
Z-score	0.693 vs 0.701

Model 3 is adjusted for age, sex, body mass index, systolic blood pressure, smoking status, prevalent diabetes mellitus, prevalent coronary events, prevalent heart failure and antihypertensive treatment.

CHI3L1, chitinase-3-like protein 1; FABP4, fatty-acid binding protein 4; GAL-4, galectin 4; GDF-15, growth differentiation factor 15; IGFBP-7, insulin-like growth factor-binding protein 7; MMP-2, matrix metalloproteinase-2; NT-proBNP, N-terminal pro-B-type natriuretic peptide; OPN, osteopontin; PON3, paraoxonase 3; TNFR1, tumour necrosis factor receptor 1; UPAR, urokinase receptor.