Rosales 1996.
Methods | Randomized, double‐blind, placebo‐controlled clinical trial | |
Participants | 200 children with acute measles not requiring hospitalization | |
Interventions | Single dose of 200,000 IU vitamin A in oil (100,000 IU for infants) or placebo | |
Outcomes | Measles‐associated cough or pneumonia, croup, fever, diarrhea Failure to improve from pneumonia | |
Notes | Quality score 5 | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | 1:1 randomization scheme was used to allocate vitamin A or placebo treatment Allocation of bottle codes for each series of 100 participants identification numbers was accomplished using a random numbers table |
Allocation concealment (selection bias) | Low risk | Adequate |
Blinding (performance bias and detection bias) All outcomes | Low risk | Double‐blinded |
Other bias | Low risk | |
Blinding of participants and personnel (performance bias) All outcomes | Low risk | |
Blinding of outcome assessment (detection bias) All outcomes | Low risk |
mo = months