Fig. 2.

Functions and regulation of PTBP1 in normal cells

PTBP1 functions mainly in neuronal cells, in which it interacts with Pnky, miR-124, PSD-95, and Pbx1. PTBP1 regulates neurogenesis, NMD, transcription of neuronal genes, and tissue repair of neurogenic cells. It also regulates CD5 via alternative polyadenylation and CD40L and IL-2 via the PLCγ1/ERK1/2 and NF-κB pathways. PTBP1 regulates apoptosis via BIM and MCL1. miR-124: microRNA-124; PSD-95: postsynaptic density protein 95; NMD: nonsense-mediated mRNA decay; BIM: BCL-2-like 11; MCL1: myeloid cell leukemia 1; REST: repressor element 1 silencing transcription factor; PLCγ1: phospholipase Cγ1; ERK: extracellular signal-regulated kinase; NF-κB: nuclear factor-κB