Table 2.
Mean (n = 2) pharmacokinetic data from the two-compartment analysis of the intravenous rat (340 g) plasma concentration-time profiles (Figure 2), including clearance (CL), volume of distribution at steady state (Vss), and both intercepts (C1 and C2) and slopes (λ1 and λ2) of the first and second terms: Individual values of rat 1 and 2 in parenthesis.
| Drug | CL (L/h) | Vss (L) | C1 (nM) | C2 (nM) | λ1 (h−1) | λ2 (h−1) |
|---|---|---|---|---|---|---|
| Enalaprilat | 0.18 (0.18/0.17) | 0.34 (0.30/0.37) | 428.6 (449.1/408.0) | 87.7 (105.5/70.0) | 3.9 (4.6/3.3) | 0.38 (0.45/0.31) |
| Hexarelin | 0.62 (0.62/0.61) | 0.22 (0.21/0.24) | 355.2 (416.9/293.5) | 133.7 (149.1/118.3) | 13.7 (17.5/10.0) | 2.08 (2.26/1.91) |