Figure 6.

Schematic illustration of synthesis of superparamagnetic iron oxide nanoparticles (SPION) functionalized with (3-Aminopropyl)triethoxysilane (APTES), after which carboxylated polyethylene glycol (PEG-COOH), folic acid (FA) and carboxylate quercetin (CQ) were conjugated on the surface via a carboxylic/amine group using the nanoprecipitation method (designated SPION@APTES@FA PEG@CQ) and its effect mechanism on cells (in a study of Alpsoy et al. [46], CQ was replaced by usnic acid). Reprinted from Ceramics International, 42, Akal, Z.U.; Alpsoy, L.; Baykal, A., Heparin appended ADH-anionic polysaccharide nanoparticles for site-specific delivery of usnic acid, 9065–9072 [47], Copyright (2016), with permission from Elsevier.