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Metabolic profiles of HSG4112(S) and HSG4112(R) in rat liver microsomes. (A) Percent remaining amounts of HSG4112(S) and HSG4112(R). (B) Relative peak areas of the metabolites generated from HSG4112(S) and HSG4112(R). HSG4112(S) and HSG4112(R) were incubated separately in rat liver microsomes for 60 min and the resulting amount of the parent drug and its metabolites was measured based on peak area.
