Table 1.
Formulation code, polymer, feed solutions’ composition, Actual Drug Content (ADC), Encapsulation Efficiency (EE), mean diameter and sphericity coefficient (SC) of only-core beads obtained by mono-nozzle prilling (F1 and F2) and core-shell beads manufactured by co-axial prilling (F3-F4-F5).
| Formulation Code | Polymer (% w/v) |
Core:Shell Mass Ratio | Drug:Core Mass Ratio | ADC (% ± SD) |
EE (% ± SD) |
Mean Diameter (mm ± SD) |
SC |
|---|---|---|---|---|---|---|---|
| F1 | Core: alg 2.0 | / | 1:20 | 3.4 ± 0.1 | 71.6 ± 2.6 | 2.01 ± 0.12 | 0.93 ± 0.01 |
| F2 | Core: pct 4.0 | / | 3.5 ± 0.1 | 72.8 ± 2.2 | 1.94±0.11 | 0.86 ± 0.04 | |
| F3 | Core: pct 4.0 Shell: alg 1.0 |
4:1 | 2.9 ± 0.2 | 75.0 ± 4.2 | 2.50 ± 0.15 | 0.83 ± 0.03 | |
| F4 | Core: pct 4.0 Shell: alg1.5 |
2.7:1 | 2.9 ± 0.1 | 81.1 ± 3.0 | 2.72 ± 0.11 | 0.86 ± 0.04 | |
| F5 | Core: pct 4.0 Shell: alg 2.0 |
2:1 | 2.7 ± 0.1 | 84.8 ± 3.7 | 2.93 ± 0.31 | 0.88 ± 0.04 |