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Characterization of the particle size, shape and solubility of rebamipide solid microparticles (REB-MPs) and nanoparticle (REB-NPs)-based ophthalmic formulation. (A) REB-MPs size by laser diffraction measurement. (B) REB-NPs size by dynamic light scattering measurement. (C) AFM image of REB-NPs. (D) Drug solubility in REB-MPs and REB-NPs. n = 6. *P < 0.05, vs. REB-MPs. 99.92% of the rebamipide existed in the solid form in REB-NPs, and the mean particle size was 109.5 nm.
