Figure 4.

Changes in rebamipide levels in the lacrimal fluid and meibum of rabbits receiving a single treatment of REB-NPs or REB-MPs. (A) Rebamipide profile and (B) AUC_LF in the lacrimal fluid after the application of REB-MPs or REB-NPs. (C) Rebamipide levels in the meibum and lacrimal fluid without meibum after the application of REB-MPs or REB-NPs. Here, 20 min and 60 min after the application of REB-NPs, the lacrimal fluid without meibum was collected from the eyelid side using Schirmer tear test strips. n = 5–7. *P < 0.05, vs. REB-MPs for each group. ^#P < 0.05, vs. lacrimal fluid without meibum for each group. The rebamipide in the REB-NPs penetrated the eyelid, and was delivered to the lacrimal fluid through the meibomian glands.