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. 2020 Feb 14;12(2):155. doi: 10.3390/pharmaceutics12020155

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Therapeutic effect of the repetitive application of REB-NPs on dry eye in the N-acetylcysteine-treated rabbit model (dry eye model). Effect of REB-NPs on (A) the lacrimal fluid volume and (B) mucin levels in the dry eye model. (C) Images of the ocular surface in the dry eye model after repetitive applications of REB-NPs. The bar indicates 1 mm. (D) Effect of REB-NPs on tear film breakup levels in the dry eye model. Rabbits were treated repetitively with REB formulations at 14:00, and the experiments were performed at 18:00. n = 5–8. *P < 0.05, vs. none for each group. ^#P < 0.05, vs. Vehicle for each group. In the dry eye model, the application of REB-NPs enhanced the lacrimal fluid volume, and normalized the decreased mucin levels. In addition, the tear film breakup levels decreased by the application of REB-NPs.