Table 2.
Efflux ratios of the studied compounds in tight RPE barriers.
| Compound | LEPI | hESC-RPE (Regea08/017) | hESC-RPE (Regea08/023) | Bovine RPE-Choroid 1 |
|---|---|---|---|---|
| Aztreonam | 4.8 | n.a. | n.a. | 1.2 |
| Ciprofloxacin | 3.9 | 1.9 | 1.1 | 6.7 |
| Dexamethasone | 1.1 | n.a. | n.a. | n.d. |
| Fluconazole | 1.5 | 1.1 | 1.1 | 1.2 |
| Ganciclovir | 2.7 | 2.9 | 1.3 | 1.5 |
| Ketorolac | 3.1 | 1.8 | 1.3 | 14.5 |
| Methotrexate | 3.0 | 4.4 | 1.8 | 2.1 |
| Quinidine | n.a. | 0.9 | 0.7 | n.a. |
| Voriconazole | n.a. | 1.1 | 1.0 | 1.2 |
1 Values collected from [2]. n.a., Papp value could not be calculated due problems in analytics (aztreonam) or rapid drug flux (dexamethasone, quinidine, and voriconazole). n.d., not determined.