Figure 1.

Cell morphology, cell to cell signaling, cellular growth, function, and morphology-related molecular interaction network assembled from retina proteins impacted by topical E₂ to OVX Brown Norway rats. The shapes (see legend in blue box) represent molecular classes of the regulated proteins. In the network, red and green colors denote upregulation and downregulation in response to E2 treatment, respectively. The intensity of color indicates the relative magnitude of fold change in protein expression pattern. Solid and dashed lines represent direct and indirect interactions, respectively. Abbreviations: CANX, calnexin; CBX5, chromobox 5; E2f, E2F transcription regulator; ERK, extracellular signal-regulated kinase; Gpcr, G-protein coupled receptor; GMPR, guanosine monophosphate reductase; Hdac, histone deacetylase; Ikb, Iκ-B; MAPK, mitogen-activated protein kinase; N-cor, nuclear receptor corepressor; Nfat, nuclear factor of activated T-cells; NMDA, N-methyl-D-aspartic acid; NUMA1, nuclear mitotic apparatus 1; PCP2, Purkinje cell protein 2; Pdgfr, platelet-derived growth factor receptor; Pka, protein kinase A; PLC, phospholipase C; Pld, phospholipase D; Rb, Rb tumor suppressor; RHO, rhodopsin; Sfk, Src family kinase; TBCC, tubulin folding cofactor C.