Fig. 6.

The effects of brief retigabine delivery via osmotic pump (750 μg/kg per hour, starting 3 hours after contusion for 10 days) on SCI-induced tissue loss in the spinal cord. Representative images in the upper panel showing EC staining of spinal cord sections from both retigabine- and vehicle-treated SCI rats. The graph in the lower panel indicates the quantification of the spared gray matter and white matter of spinal cords at the epicenter of the contusion site from vehicle- and retigabine-treated SCI rats. P = 0.045, t₍₅₎ = 2.648, for white matter between vehicle and retigabine groups. Unpaired student t test (two-tailed); P = 0.229, U = 2.0, for gray matter between vehicle and retigabine groups. Mann-Whitney rank sum test. Dots in each column represents an animal. *P < 0.05. Retig, retigabine; Veh, vehicle.