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Effect of rifampin pre-treatment on the liver to plasma concentration ratios of compound K in (A) rats and (B) mice. Liver and plasma compound K concentration were measured following intravenous injection of compound K at a single dose of 2 mg/kg in the presence or absence of rifampin pre-treatment (20 mg/kg, per oral). Data expressed as mean ± standard deviation from four rats or four mice at different time points. *: p < 0.05 compared with control group.
