. 2020 Feb 3;12(2):129. doi: 10.3390/pharmaceutics12020129

Table 5.

Pharmacokinetic parameters of compound K in rats of bile cannulation and non-bile cannulation.

Characteristics	Parameters	Non-Bile Cannulated Rat	Bile Cannulated Rat
Plasma	C₀ (ng/mL)	451.13 ± 192.5	436.25 ± 325.8
	AUC_{12 h} (ng∙h/mL)	496.38 ± 253.1	211.09 ± 87.32 *
	AUC_∞ (ng∙h/mL)	517.19 ± 248.6	234.78 ± 125.6 *
	T_1/2 (h)	2.40 ± 0.61	0.78 ± 0.11 *
Excretion	Bile_{12 h} (% of dose)	-	39.1 ± 5.7

C₀: initial plasma concentration; AUC_{12 h} or AUC_∞: area under the plasma concentration-time curve from 0 to last sampling time or infinity; T_1/2: half-life. Data expressed as mean ± standard deviation from four rats. *: p < 0.05 compared with non-bile cannulated rat group.