TABLE 1.
Expression levels of enzymes (P450 and UGT) with known involvement in drug metabolism in human intestine
Protein expression is represented by the mean, the S.D. of the mean, the %CV, and the range (min-max). Protein abundance is reported in picomoles per milligram of total mucosal protein.
| Jejunum (n = 4) | Ileum (n = 12) | |
|---|---|---|
| Mean ± S.D. (%CV) and Range (min-max) | Mean ± S.D. (%CV) and Range (min-max) | |
| CYP2C9 | 1.52 ± 0.61 (40.32) | 1.42 ± 0.60 (42.11) |
| (0.81–2.17) | (0.92–3.04) | |
| CYP2C19 | 1.08 ± 0.11 (10.16) | 1.25 ± 0.60 (47.78) |
| (0.99–1.23) | (0.79–3.04) | |
| CYP2D6 | 1.91 ± 0.46 (23.90) | 1.64 ± 0.55 (33.54) |
| (1.31–2.30) | (1.00–2.63) | |
| CYP2J2 | 1.04 ± 0.30 (28.52) | 0.90 ± 0.16 (17.90) |
| (0.72–1.43) | (0.62–1.11) | |
| CYP3A4 | 33.33 ± 5.70 (17.11) | 22.04 ± 10.60 (48.10) |
| (24.80–36.75) | (7.58–34.70) | |
| UGT1A1 | 2.93 ± 2.17 (73.83) | 1.52 ± 0.55 (36.50) |
| (0.83–5.35) | (0.72–2.58) | |
| UGT1A3 | 1.26 ± 0.29 (22.64) | 1.10 ± 0.23 (20.50) |
| (0.87–1.54) | (0.90–1.69) | |
| UGT1A6 | 0.75 ± 0.02 (2.12) | 0.75 ± 0.02 (3.25) |
| (0.74–0.77) | (0.71–0.79) | |
| UGT2B7 | 1.84 ± 0.97 (53.07) | 1.17 ± 0.23 (19.34) |
| (1.03–3.03) | (0.88–1.65) | |
| UGT2B15 | 0.39 ± 0.03 (8.37) | 0.37 ± 0.03 (9.26) |
| (0.34–0.41) | (0.32–0.44) |