TABLE 2.
Expression levels of one plasma membrane marker (Na+/K+-ATPase), one cell adhesion protein (cadherin-17), and drug transporters with known involvement in drug clearance in human intestine
Protein expression is represented by the mean, the S.D. of the mean, the %CV, and the range (min-max). Protein abundance is reported in picomoles per milligram of total mucosal protein.
| Transporter | Jejunum (n = 4) | Ileum (n = 12) |
|---|---|---|
| Mean ± S.D. (%CV) and Range (min-max) | Mean ± S.D. (%CV) and Range (min-max) | |
| Na+/K+-ATPase | 18.86 ± 4.35 (23.07) | 13.46 ± 4.62 (34.32) |
| (14.88–24.01) | (5.71–23.39) | |
| Cadherin-17 | 21.02 ± 6.25 (29.73) | 13.49 ± 4.49 (33.26) |
| (15.70–28.83) | (7.07–23.10) | |
| P-gp | 0.74 ± 0.22 (29.50) | 0.96 ± 0.56 (58.57) |
| (0.54–1.05) | (0.25–2.05) | |
| MRP2 | 3.33 ± 0.76 (22.80) | 2.66 ± 0.65 (24.49) |
| (2.76–4.43) | (2.02–3.98) | |
| BCRP | 0.59 ± 0.27 (45.94) | 0.45 ± 0.13 (28.03) |
| (0.33–0.95) | (0.21–0.69) | |
| OST-α | 1.91 ± 0.15 (7.62) | 2.34 ± 0.58 (24.69) |
| (1.80–2.12) | (1.62–3.39) | |
| OST-β | 1.72 ± 0.24 (14.02) | 1.88 ± 0.39 (20.50) |
| (1.50–1.97) | (1.18–2.60) | |
| OATP2B1 | 2.65 ± 1.95 (73.37) | 3.71 ± 2.50 (67.49) |
| (1.19–5.47) | (0.21–7.51) | |
| OATP1A2 | 1.50 ± 0.04 (2.88) | 1.59 ± 0.31 (19.40) |
| (1.44–1.54) | (1.44–2.46) |