Fig. 1.

Effects of acute pretreatment of CP 55,940 (0.001–0.01 mg/kg, i.v.) (A), Δ⁹-THC (0.03–0.3 mg/kg, i.v.) (B), or rimonabant (0.3–3.0 mg/kg, i.v.) (C) on choice between cocaine and food in rhesus monkeys (n = 4). Ordinate: percent of reinforcers earned on the cocaine-associated switch. Abscissae: unit dose of cocaine in milligrams per kilogram per injection available as an alternative to a food pellet. All data represent means ± S.E.M. of four monkeys for at least two determinations of acute pretreatment of vehicle (filled symbols) or each test drug (open symbols). *P < 0.05 compared with respective vehicle pretreatment.